2020-21 SAEMF Research Large Project Grant - $150,000

“Psychological Contributors to Cardiovascular Disease Risk in ED Patients”

There is a critical need to identify individuals who are at risk for coronary artery disease (CAD) secondary to anxiety and depression in the ED and define the interplay between the two disease states, so effective interventions aimed at reducing CAD development can be implemented. It has been shown that anxiety and depression symptoms are linked to nitric oxide (NO) mediated, endothelial cell-vascular smooth muscle (EC-VSM) hyporesponsiveness to shear stress.


  • Paul I. Musey, Jr., MD, MSc


    Indiana University School of Medicine

    I am an Associate Professor of Emergency Medicine and currently the Division Chief for Research and Vice-Chair for Innovation for Emergency Medicine at Indiana University School of Medicine. I attended medical school at Emory University in 2009 before completing an Emergency Medicine residency at Carolinas Medical Center in Charlotte, NC in 2012. I had the opportunity to stay on as faculty for the next 1.5 years before moving to Indiana University School of Medicine where I completed an Emergency Medicine Research Fellowship and obtained a Masters in clinical research. My research interest revolves around the evaluation and management of psychological contributors to ED presentations and is currently focused on low-risk chest pain.

    I am currently PI or site PI for a number of ED clinical studies in this area and have received funding from the Emergency Medicine Foundation, the Society for Academic Emergency Medicine Foundation, and most recently a $3 million award from the Patient-Centered Outcomes Research Institute (PCORI) for a randomized comparative effectiveness trial of stepped intensity psychological treatment options for ED patients with low-risk chest pain associated with anxiety. In 2023 I took over as Medical Director for Enterprise Clinical Research Operations for IU Health charged with implementing and supporting high-impact clinical trials for the health system.