SAEMF Research Large Project Grant - $149,233

"Targeting VWF Hyperadhesiveness to Improve Organ Perfusion After Trauma"

The burden of trauma is staggering, accounting for outsized morbidity and mortality and approximately one in five emergency department visits in the United States. This project will focus on a specific pathway implicated in the impairment of organ perfusion after trauma that contributes to poor patient outcomes. It will deepen our understanding of the pathophysiology of this process, test two promising interventions for further development, and support future research in this critical area.

Recipient(s)

  • Alexander St. John, MD, MS

    Alexander St. John, MD, MS

    University of Washington

    "Targeting VWF Hyperadhesiveness to Improve Organ Perfusion After Trauma"

    Alexander St. John, MD, MS, is a physician-scientist in the Department of Emergency Medicine at the University of Washington School of Medicine.

    Dr. St. John’s research focuses on improving outcomes for trauma patients by advancing understanding of maladaptive processes following severe injury. His work examines trauma-induced coagulopathy and systemic microvascular obstruction as key drivers of organ dysfunction.

    His research aims to generate foundational insights that inform the development of new therapeutic strategies to expand clinical approaches for treating these conditions.